Antidepressants have recently been shown to have anti-inflammatory properties. Venlafaxine is an antidepressant that inhibits serotonin and norepinephrine reuptake. Venlafaxine's anti-inflammatory effects have been explored in a variety of research and models, including animals and people. The goal of this study was to see how effective venlafaxine is at reducing inflammation.
Materials and Methods:
In a rat model of acetic acid-induced colitis, the anti-inflammatory effects of venlafaxine were studied. Colitis induced in rats by administering 2-ml from 4% acetic acid. Six groups were formed following colitis induction: group 1 received no medication, group 2 received actic acid, group 3 received dexamethasone, and groups 4, 5 and 6 received 10, 20 and 40 mg/kg venlafaxine i.p. two hours after colitis induction and for four days daily. Dexamethasone (1 mg/kg, i.p.) was used as a control. Colonic inflammation was assessed by macroscopic inspection, pathological investigation, and myeloperoxidase activity measurements.
Results:
The acetic acid group demonstrated severe inflammation, ulceration, bleeding, and necrosis after induction of colitis, whereas venlafaxine at doses of 20 and 40 mg / kg and also dexamethasone, Animalanimal colonic tissue had drastically improved colitis parameters. In comparison to acetic acid and a control group. In rat model of induced colitis, venlafaxine reduced indications of inflammation, decreased increased MPO, and improved the pathological picture both micro and macro.